Enhancement of rIn:rCn-induced interferon production by amphotericin B.
نویسندگان
چکیده
When mouse L929 cells are treated with amphotericin B before exposure to polyriboinosinic-polyribocytidylic acid or polyriboinosinic-polyribocytidylic acid-dextran, they make significantly more interferon than do cells not receiving amphotericin. This effect may be due to enhanced cell membrane penetration by the polynucleotide.
منابع مشابه
Mechanistic studies of polyene enhancement of interferon production by polyriboinosinic-polyribocytidylic acid.
The production of interferon by polyriboinosinic-polyribocytidylic acid [poly(I) . poly(C)] and poly(I) . poly(C)-diethylaminoethyl-dextran in L929 cells was enhanced from 10 to 100 times by polyene macrolides, including amphotericin B (AmB), AmB methyl ester, nystatin, and filipin. AmB and its water-soluble methyl ester were the most effective; retinol, a nonmacrolide polyene, was ineffective....
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 9 3 شماره
صفحات -
تاریخ انتشار 1976